Brcatwohithypothesis

由 JA Menendez 著作 · 2016 · 被引用 16 次 — Alfred Knudson proposed the “two-hit” hypothesis to explain the early onset at multiple sites in the body of an inherited form of cancer ...

由 N Premnath 著作 · 2020 · 被引用 6 次 — BRCA genes follow Knudson's two hit hypothesis where the second hit in the wild type allele of a germline mutation carrier is accrued by loss of allele or ...

由 F Meric-Bernstam 著作 · 2007 · 被引用 25 次 — Heterogenic loss of BRCA in breast cancer: the two-hit hypothesis takes a hit.

由 F Meric-Bernstam 著作 · 2007 · 被引用 25 次 — The two-hit hypothesis suggests that loss of a single functional allele, which may potentially result in expression of a truncated or mutated ...

The two-hit hypothesis provided a unifying model for understanding cancer that occurs in individuals who carry a susceptibility gene and cancers that ...

由 D Stoppa-Lyonnet 著作 · 2016 · 被引用 110 次 — Tumourigenesis in germline BRCA1/2 pathogenic mutation carriers generally follows a two-hit hypothesis, the first 'hit' owing to the ...

由 JP Issa 著作 · 2022 · 被引用 9 次 — Knudson formulated the two-hit hypothesis to explain familial versus sporadic cancer epidemiology, proposing that the same genes are involved in ...

Thus, in order for a particular cell to become cancerous, both of the cell's tumor suppressor genes must be mutated. This idea is known as the two-hit ...

The Knudson hypothesis, also known as the two-hit hypothesis, is the hypothesis that most tumor suppressor genes require both alleles to be inactivated, ...